ÉQUILIBRE BERBÉRINE PREMIUM

What is ÉQUILIBRE BERBÉRINE PREMIUM?

Synergy based on highly bioactive Berberine for metabolic regulation.

DIRECTIONS :

Take 1 to 3 gelcaps a day, 30 minutes before a meal or as otherwise recommended.

This is a 3-month renewable treatment.

Are you having trouble swallowing the gelcaps?

You can open the gelcaps and pour the contents into a glass of water, fruit juice, puree or yoghurt.

• Consume with a varied, balanced diet and a healthy lifestyle.

• Respect the recommended daily doses

• Keep out of the reach of children 

•  Not recommended for pregnant women due to the presence of isoquinoline alkaloids, such as berberine, which could increase uterine contractions.

• Not recommended for women who are breast-feeding, children and adolescents, diabetics, those with liver or heart problems, or people taking medication.

Nutritional information :

* Nutrient Values of Reference

Ingredients

Berberine LEO HB® (hydrolyzed collagen, berberine hydrochloride from Berberis aristata/Berberis vulgaris roots, humectant: glycerol), Envelope shell: pulluan plant-based gelcaps, Bulking agent: acacia fibers, Vitamin B3, Chromium picolinate.

The manufacturer is ISO 22000 certified.

• LEO HB® berberine extract is far more bioavailable than native berberine.

• LEO HB® berberine extract is produced in a clean-label process, using natural methods with no addition of synthetic solvents or additives.

Selected active ingredients: Berberine hydrochloride, min 95% (Berberis aristata roots)

After formulation: Dispersed and soluble in water, min 85% (very high bioaccessibility) - pH independent



Natural berberine is characterized by a bioaccessibility (solubility and dispersion) that varies greatly with pH.  The doses traditionally used range from 400 to 1,500 mg per day, and taken several times a day.

LEO-BERBERINE HB is characterized by a bioaccessibility (solubility and dispersion) of min 85% over the entire pH range (native berberine, by contrast, has an average solubility of between 15 and 20% in acidic media).

LEO-BERBERINE diagram

Solubilization of LEO BERBERINE HB after formulation (solid-solid microdispersions) vs. native BERBERINE solubilization (equivalent berberine masses) - pH 1.2

LEO-BERBERINE HB is protected by a Belgian patent (BE1025649) and by application of an international patent.